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It seems to me that thiel is arguing it’s easier to make money or create impact by finding a new niche and occupying it instead of competing for a spot at existing niches. This perspective is probably only valid in the tech industry? Only the tech industry is booming all the time with new niches emerging every so often. Other industries are quite fixed. And we are only seeing the quick emergence of new economic niches because we are going through a tech revolution. It’s possible that such rate of progress subsides eventually and thiel’s model wouldn’t work anymore. But so far his idea seems valid from an individual perspective (as in I know I am moral and will use my company for good impacts)

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